The foundation of the Center of Excellence in Inflammation, Infectious Disease and
Immunity is research. 
CIIDI's dedicated teams of highly trained investigators are working diligently to learn about, treat and cure human diseases.
临床与转化研究
人类免疫缺陷病毒（HIV）
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HIV (human immunodeficiency virus) is a virus that attacks the body's immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). There is currently no effective cure.
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HIV/HCV合并感染的免疫发病机制及其对先天免疫应答的关注
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Basic immunologic mechanisms underlying EBV latency and EBV/HIV co-infection leading to tumorigenesis
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HIV感染期间的免疫反应和潜伏期
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丙型肝炎（HCV）
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Hepatitis C is a viral infection that causes liver inflammation, sometimes leading to serious liver damage. The hepatitis C virus (HCV) spreads through contaminated blood.
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单核细胞和细胞功能
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DNA修复
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乙型肝炎（HBV）
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Hepatitis B is a serious liver infection caused by the hepatitis B virus (HBV). For most people, hepatitis B is short term, also called acute, and lasts less than six months. But for others, the infection becomes chronic, meaning it lasts more than six months.
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患有慢性乙型肝炎会增加以下疾病的风险：
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肝衰竭
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肝癌
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肝硬化——一种永久性损伤肝脏的疾病。
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COVID-19
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The Center of Excellence in Inflammation, Infectious Disease and Immunity (CIIDI) is leading the way in novel approaches to identifying the root causes of ongoing and newly developed symptoms of Long Covid.
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博士。 Jonathan Moorman has established a repository of patient specimens used for testing human cells for their immune response to COVID-19, and for use in future research studies.
训练有素的免疫力
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Trained immunity is a functional state of the innate immune response and is characterized by long-term epigenetic reprogramming of innate immune cells.
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先天免疫细胞的训练，例如：
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单核细胞
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巨噬细胞
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自然杀伤细胞
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脓毒症
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脓毒症 is a heterogenous disease state that can be divided into degrees of severity, typically sepsis, severe sepsis, and septic shock. Patients suffering from the latter classifications are frequently on a ventilator and/or have altered mentation.
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定理:
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脓毒症/感染性休克的细胞和分子机制
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败血症的先天免疫与心肌功能障碍
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先天免疫识别与真菌细胞壁
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生物技术
蛋白质组学
A branch of biotechnology concerned with applying the techniques of molecular biology, biochemistry, and genetics to analyzing the structure, function, and interactions of the proteins produced by the genes of a particular cell, tissue, or organism, with organizing the information in databases, and with applications of the data.
基因组学
基因组学 is branch of biotechnology concerned with applying the techniques of genetics and molecular biology to the genetic mapping and DNA sequencing of sets of genes or the complete genomes of selected organisms, with organizing the results in databases, and with applications of the data.
聚集规律间隔回文重复序列(CRISPR)/Cas9
姚志强博士，医学博士，博士 is targeting specific HIV and HBV DNA that has no overlap with the human genome using CRISPR/Cas9 gene editing drugs delivered by nanoparticles. Once in-vitro studies are concluded (with sig. p-value), this “discovery project” will assist in the development of a new nanocarrier for effective intracellular delivery and sustained release of CRISPR/Cas9 ribonucleoprotein (RNP).
*If successful, project will provide a novel technology platform that may be used in combatting other emerging viral diseases.
药物发现与合成
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Vaccine adjuvants augment and help guide immune responses to antigens, the vaccine components that elicit pathogen-specific immune responses.
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药物发现和合成核心focuses on developing innovative immune therapies, as well as the discovery of new and novel adjuvants for increasing vaccine effectiveness.
大卫·l·威廉姆斯博士是差研究人员的领军人物 国际研究 which found that fungal sugars called mannans can boost vaccine effectiveness against respiratory viruses.
Uthsc生物储存库和整合基因组学（大）倡议
- Purpose: The goal of the BIG Initiative is to facilitate research in precision medicine relevant to clinical care across the state by developing resources to link and analyze genetic, health, and demographic data in these various populations. The BIG Initiative seeks to address the most-pressing health care needs in Tennessee, caring for vulnerable populations, eliminating health disparities, and engaging participating communities through innovative programs.
- Process: Patients will be asked to participate in research and consent to one extra tube of blood to be drawn along with ordered lab tests. Participation in this research is always voluntary. If you wish to have your blood samples withdrawn, please contact us at (423) 439-4768.
- Benefits: You will likely not benefit from this study, but the collection of your blood and medical data may contribute to studies leading to the improvement in health outcomes of others in the future.
- 安全: Safeguards are in place on all participant health information. All samples are de-identified; no names, birthdays, or other patient information will ever be included. The federal government through the Genetic 信息rmation Nondiscrimination Act protects genetic information.
- Risks: There is an inherent risk of bacterial infection, pain, and loss of consciousness during venipuncture in routine labs; the additional sample does not increase this risk. The greatest risk to you is the release of your private information. There is potential loss of confidentiality, since your de-identified medical record is shared with UTHSC.
弗吉尼亚州盾
VA Science and Health Initiative to Combat Infectious and Emerging Life-Threatening Diseases (VA SHIELD) is a comprehensive, secure biorepository of specimens and associated data. These specimens and data are available to authorized VA investigators—and, under certain circumstances, to their external collaborators—to advance scientific understanding in support of developing diagnostic, therapeutic, and preventative strategies for use in clinical care.
Etsu研究公司
